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CustOm-made aNTibacterical/bioActive/bioCoaTed prostheses (C.O.NT.A.C.T.)
The aim is to produce custom-made bioactive maxillofacial implants through the creation of suitable surface features, be it presence of an apatitic layer or a microporous surface on the (necessary) surface locations of prostheses made of Titanium or Magnesium alloys, both manufactured by SuperPlastic Forming or Single Point Incremental Forming. A wide span of clinical cases will be covered, ranging from large prosthetic permanent Ti implants to small temporary Mg ones.
Description of Projectidea
Custom-made MaxilloFacial Implants (MFI) shall be fabricated by Super Plastic Forming (SPF) and Single Point Incremental Forming (SPIF) thanks to the experience gained during the Project of Relevant National Interest (PRIN) funded by Italian Ministry of Education and Research (www.BioForming.it). Case studies should be, for example, cranial prostheses, denture base and/or implants characterised by small thickness. The possibility of further improving the performance of the manufactured prostheses, in terms of bioactivity and capabilities to accelerate the osseo-integration, shall be investigated through: (i) the creation of a suitable micro-texturing on the bone-metal interface surface of the implant; (ii) the deposition of desired elements (mainly Ca and P) on the implant during the SPF process, to activate the in-vitro formation (i.e. while the prosthesis is immersed in a body-like environment) and growing of apatite. Functionalization by micro-texturing shall be investigated creating the features directly on the fabricated MFI or, in the case SPIFed prostheses, on the die surface. Surface modification of Ti and Mg alloys MFI by Anodic Spark Deposition (ASD) treatment, also known as Plasma Electrolytic Oxidation (PEO) or Micro Arc Oxidation (MAO), shall be also investigated. In particular, Ti surfaces shall be modified at the nano- and microscale by an ASD treatment to improve the implant to bone interface and to provide long term biocompatible antibacterial capabilities. ASD technique will also be researched and applied to Mg alloys with a twofold goal: (i) to improve corrosion resistance for better degradation control of Mg alloys; (ii) to improve cytocompatibility and metal/bone interface. In this project, ASD treatment will be performed using proper electrochemical solutions followed, in case, by chemical post treatments. Numerical and computational modelling of the interaction between the prosthesis and the surrounding body tissue shall be carried out in order to investigate the cells adhesion, its spreading and proliferation. The antibacterial and bioactivity of the MFI surfaces shall be investigated by in vitro analyses. In vitro tasks will be aimed to functionalise and test the biocompatibility of hMSCs an Osteocytes, as well as key-factors such as cell morphology, cell distribution on materials and cell commitment with and without conditioned medium.
Consortium of partners, already involved
Academic partners (Italian, but applying to 2 different funding organizations): design of the prostheses and its connection; fabrication of the prostheses by SPF and SPIF; surface modification of the prostheses by ASD; coating and biological testing of the prostheses surface.
SME: in vitro analyses
Partners sought to complete the consortium
1. Academic and or Industrial European partner able to perform LST texturizing treatments (on both Prostheses and SFP dies).
2. Industrial European partner able to scale up the lab treatments to an industrial process .
3. Academic and or Industrial European partners able to conduct in vitro/vivo analyses for assessing the antibacterial and bioactivity of the MFI surfaces.
M-ERA.NET 5 - 2016:
Interfaces between materials and biological hosts for health applications
Associate Professor Gianfranco Palumbo
Politecnico di Bari - Department of Mechanical Engineering, Mathematics & Management Engineering
Viale Japigia, 182
Organisation: Higher Education
Ms Serena Borgna
Telephone:0039 (0)6 93 99 93
Telefax:0039 (0)6 48 90 25 50